Science-Driven Solution for Hydration & Firmness

MESOHEAL® Bio with ACAPLEX™

MESOHEAL® Bio with ACAPLEX™ is a science-driven skin rejuvenation treatment designed to support skin hydration, firmness, elasticity, and overall skin quality.

Combining ACAPLEX™ technology with 1.5% medium- and high-molecular-weight Hyaluronic Acid (HA), the formulation is designed to support the extracellular matrix (ECM) while providing deep and long-lasting hydration.

The Science Behind Skin Ageing

As we age, prolonged exposure to ultraviolet (UV) radiation and environmental aggressors such as oxidative stress and pollution can accelerate changes within the extracellular matrix (ECM).

The gradual deterioration of the ECM can compromise skin integrity and structural support, contributing to visible signs of ageing, including:

  • Loss of firmness and elasticity
  • Fine lines and wrinkles
  • Uneven or rough skin texture
  • Dehydration
  • Dullness and loss of radiance
  • Premature signs of ageing

MESOHEAL® Bio with ACAPLEX™ is designed to address these concerns by combining ECM-supporting ingredients with high-performance hydration.

01
ACAPLEX™

Advanced ECM-Supporting Technology

ACAPLEX™ is an advanced formulation combining two key components:

KORU-ACA01™ Peptide
Bio-identical Type III Collagen

This combination is designed to work synergistically to support and protect the extracellular matrix (ECM), helping maintain the structural integrity, firmness, and elasticity of the skin.

ACAPLEX™ is designed to support:

  • ECM regeneration
  • Collagen and elastin preservation
  • Skin structural integrity
  • Skin firmness and elasticity
  • Skin recovery and regeneration
  • A smoother and more youthful-looking appearance
02
KORU-ACA01™ PEPTIDE

Precision Bioengineered Peptide for ECM Support

KORU-ACA01™ Peptide, developed by the Koru Pharma R&D Institute, is a precision-bioengineered peptide designed to mimic the signalling role of the GH2 hormone.

The peptide is designed to support ECM integrity by helping preserve collagen structure and reinforce skin architecture.

By targeting key processes involved in ECM maintenance, KORU-ACA01™ is designed to support skin firmness, elasticity, and overall skin revitalisation.

How KORU-ACA01™ Works

1. Supports ECM Regeneration

KORU-ACA01™ supports the regeneration of essential ECM proteins, helping maintain the skin’s natural structural framework.

This process contributes to:

  • Tissue renewal
  • Improved skin strength
  • A firmer-looking appearance
  • More even skin texture

2. Helps Reduce ECM Breakdown

KORU-ACA01™ has demonstrated activity against enzymes involved in the breakdown of collagen and elastin.

By helping limit ECM degradation, the peptide supports the preservation of skin firmness and elasticity.

3. Supports ECM Stability

By supporting ECM proteins while influencing ECM-degrading enzymes, KORU-ACA01™ is designed to help maintain the structural integrity of the extracellular matrix.

This provides ongoing support for skin resilience, firmness, and elasticity.

SAFETY TESTING

KORU-ACA01™ Safety Testing

01
CELL VIABILITY STUDY

In-Vitro Cell Viability Study

Skin safety is an important consideration in peptide development. KORU-ACA01™ underwent an in-vitro cytotoxicity assay using HS68 human dermal fibroblast cells to evaluate its effect on cell viability.

→
02
SAFETY RESULTS

Tested Safety & Tolerance

The test demonstrated no observed cytotoxicity across the concentrations evaluated.

In-vitro findings are laboratory results and should not be interpreted as a guarantee of clinical outcomes or individual tolerance.

→
03
RESEARCH BACKGROUND

Study Details & Cell Line

The study was designed by the Koru Pharma R&D Institute and conducted in September 2022.

HS68 is a human dermal fibroblast cell line commonly used in laboratory research to evaluate skin-cell viability and safety.

COLLAGEN-RELATED PROCESSES

KORU-ACA01™ and Procollagen Production

KORU-ACA01™ was evaluated in an in-vitro study using human dermal fibroblast cells to assess its effect on procollagen production and selected ECM-degrading enzymes.

01

Procollagen Production

Demonstrated activity in supporting and stimulating the biosynthesis of procollagen in human dermal fibroblast cells.

02

Collagenase Inhibition

Helps inhibit collagenase enzymes, supporting the maintenance of existing collagen structures within the skin matrix.

03

Elastase Inhibition

Shows targeted activity in inhibiting elastase enzymes, assisting in the protection of skin elasticity and firmness.

04

MMP-1 Inhibition

Inhibits Matrix Metalloproteinase-1 (MMP-1), an enzyme responsible for breaking down interstitial collagens.

05

Comparison with Copper Peptide

Copper peptide is a widely recognised cosmetic ingredient associated with skin renewal and collagen-related processes. In the company’s in-vitro testing, KORU-ACA01™ demonstrated greater stimulation of procollagen production than copper peptide at the concentrations tested.

Enzyme Inhibition Studies

Collagenase, Elastase & MMP-1
KORU-ACA01™ was also evaluated for its ability to inhibit enzymes associated with ECM degradation.
Collagenase Inhibition
Laboratory testing demonstrated concentration-dependent collagenase inhibition by KORU-ACA01™.
Supporting collagen preservation may help maintain the structural integrity and firmness of the skin.
Elastase Inhibition
KORU-ACA01™ demonstrated elastase-inhibitory activity in laboratory testing.
Because elastase is involved in the degradation of elastin, supporting elastin preservation may contribute to maintaining skin elasticity.
MMP-1 Inhibition
KORU-ACA01™ demonstrated concentration-dependent inhibition of MMP-1 in the laboratory assessment.
MMP-1 is an enzyme involved in collagen degradation. Supporting the preservation of collagen may help maintain skin structure and resilience.

ADVANCED SKIN STRUCTURE

Bio-identical
Type III Collagen

Supporting Skin Structure & Elasticity. Type III collagen is an important component of the extracellular matrix and contributes to the structural organisation and elasticity of skin and connective tissue.

Skin Firmness ECM Resilience Cell Interaction Regeneration
KEY BENEFITS OF BIO-IDENTICAL TYPE III COLLAGEN
01
REPAIR & REGENERATION
Supports Skin Repair

Supports the skin’s natural repair and regeneration processes effectively.

02
STRUCTURAL INTEGRITY
Reinforces Framework

Helps support the skin’s structural framework and overall firmness.

03
FLEXIBILITY
Supports Elasticity

Contributes to maintaining the flexibility and integrity of the extracellular matrix.

04
ECM RESILIENCE
Enhances Resilience

Supports structural resilience, helping maintain smoother and firmer-looking skin.

TARGETED ECM SUPPORT MEETS ADVANCED HYDRATION

ACAPLEX™ + 1.5% Hyaluronic Acid

A healthy and well-supported extracellular matrix provides an important foundation for stronger, healthier-looking skin. MESOHEAL® Bio with ACAPLEX™ combines the ECM-supporting benefits of ACAPLEX™ with 1.5% Hyaluronic Acid containing medium- and high-molecular-weight HA.

ACAPLEX™

  • Supports skin firmness
  • Supports elasticity
  • Helps maintain ECM integrity
  • Supports skin regeneration
  • Helps improve the appearance of fine lines and uneven texture

1.5% Hyaluronic Acid

  • Provides intensive hydration
  • Helps improve skin softness
  • Supports smoother skin texture
  • Helps support the skin barrier
  • Promotes a plumper, healthier-looking appearance
  • Provides long-lasting hydration
The Combined Approach

Structural support + intensive hydration = healthier-looking, smoother, firmer, and more radiant skin.